0852. Selective decontamination of the digestive tract modulates the metabolic profile in a ventilator-induced lung injury model
نویسندگان
چکیده
Introduction Acute lung injury induced by mechanical ventilation [ventilator-induced lung injury (VILI)]is characterized by a particular metabolic profile in the lung and in the systemic compartment [1]. Also, VILI has been associated with an increase in intestinal permeability [2]. We hypothesized that selective decontamination of the digestive tract (SDD) can modulate the metabolic profile associated with mechanical ventilation.
منابع مشابه
Selective decontamination of the digestive tract.
Ventilator-associated pneumonia usually originates from the patient's oropharyngeal microflora. In selective digestive decontamination, topical antibiotics are applied to the oropharynx and stomach for prevention of pneumonia and other infections, possibly reducing infection-related mortality. Selective digestive decontamination is also used for the prevention of gut-derived infections in acute...
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anastomotic leakage after total gastrectomy with local decontamination. A prospective, randomized, doubleblind, placebo-controlled multicenter trial. Ann Surg 1997; 225: 172–180. 21 Stoutenbeek CP, van Saene HK, Zandstra DF. Prevention of multiple organ failure by selective decontamination of the digestive tract in multiple trauma patients. In: Faist E, Baue AE, Schildberg FW, eds. The Immune C...
متن کاملReview: several interventions prevent ventilator associated pneumonia in critically ill patients.
Conclusions Semirecumbent positioning, stress ulcer prophylaxis (sucralfate rather than H2 antagonists), aspiration of subglottic secretions, selective digestive tract decontamination, and oscillating beds reduce ventilator associated pneumonia (VAP) in select critically ill patients. No evidence currently supports specific methods of enteral feeding or increased frequency of ventilator circuit...
متن کاملShould selective digestive decontamination be used in critically ill patients?
Healthcare associated infection represents a major burden for critically ill patients; a recent point prevalence survey by the Health Protection Agency observed that 23.4% of patients in intensive care units had evidence of a healthcare associated infection.Ventilator associated pneumonia remains the leading cause of nosocomial infection in this population, and, although recent estimates of att...
متن کاملSelective digestive decontamination is superior to selective oropharyngeal decontamination
are interested in the debate on the effi cacy and safety of selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) raised by Schultz and Haas in their review [1]. Th e authors concluded that 'SDD and SOD are equally eff ective with respect to the prevention of mortality' [1]. Th is statement is based on the results of a Dutch randomized controlled trial [2],...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2014